Propanal - CH 3 CH CHO - Aldehyde; Acetaldehyde - CH 3 CHO - aldehyde; Two carboanions are formed from propanal and acetaldehyde. Aldol Condensation: the dehydration of Aldol products to synthesize α, β unsaturated carbonyl (enones) The products of aldol reactions often undergo a subsequent elimination of water, made up of an alpha-hydrogen and the beta-hydroxyl group. Crossed aldol condensation is done between acetaldehyde and acetophenone by using NaOH as the base. So, here we can get 4 possible products. So those two carboanions can react with both propanal and acetaldehyde to give four different products. Base-catalyzed elimination occurs with heating. An acidic or basic solution can catalyze the condensation of aldol. Aldol Condensation: the dehydration of aldol products to synthesize α, β unsaturated carbonyls (enones) The products of aldol reactions often undergo a subsequent elimination of water, made up of an alpha-hydrogen and the beta-hydroxyl group. Cinnamaldehyde is formed as the only crossed aldol product when acetaldehyde (enolizable) reacts with benzaldehyde (non-enolizable) in basic medium. I know that acetaldehyde will act as electrophile to which addition will occur. About Aldol condensation Two molecules of an aldehyde or a ketone undergo condensation in the presence of a base to yield a β-hydroxyaldehyde or a β-hydroxyketone. Only one crossed aldol product is formed when one of the carbonyl compound lacks α-hydrogen. The nucleophile is generally an enolate of an aldehyde or ketone attacking another aldehyde or ketone molecule. Dehydration may be accompanied by decarboxylation when an activated carboxyl group is present. E.g. This reaction is called the aldol condensation which may be exemplified by the reaction of acetaldehyde to give acetaldol (3 … Depending on the nature of the … The first part of this reaction is an aldol reaction, the second part a dehydration—an elimination reaction (Involves removal of a water molecule or an alcohol molecule). Generally speaking, an aldol condensation is a nucleophile attack on a carbonyl to make a ketone or aldehyde of β-hydroxy. Note: In above reaction, the self aldol condensation of acetaldehyde is a competing reaction. Step-1:In reverse order, The hydroxide ion deprotonates the aldehyde.Step-2:Here Enolate ion 1 adds to the unreacted aldehyde.Step-3:Alkoxide ion 2 is protonated by water.Step-4:A small amount of aldol is converted into enolate ion (4) by hydroxide ion.Step-5:Here Enolate Ion(4) loses a hydroxide ion.Step 1 to step 3 illustrates the aldol reaction. The nucleophile is generally an enolate of an aldehyde or ketone attacking another aldehyde or ketone molecule. The product of this β -elimination reaction is an α,β-unsaturated aldehyde or ketone. The product of this \(\beta\)-elimination reaction is an α,β-unsaturated aldehyde or ketone. Acetaldehyde aldol condensation mechanism All of the aldol products formed between propanal and acetaldehyde in NaOH. But which one would be the major? Generally speaking, an aldol condensation is a nucleophile attack on a carbonyl to make a ketone or aldehyde of β-hydroxy. The aldol addition product can be dehydrated via two mechanisms; a strong base like potassium t-butoxide, potassium hydroxide or sodium hydride in an enolate mechanism, or in an acid-catalyzed enolmechanism. An acidic or basic solution can catalyze the condensation of aldol.
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